Linker Information
General Information of This Linker
| Linker ID |
LIN0BQPQS
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| Linker Name |
WO2023173026A1-ADC-L078-093-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H57N7O14S
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(CCN1C(C(S)CC1=O)=O)=O)=O)C(NC(CCCNC(N)=O)C(NC2=CC=C(COC(O)=O)C=C2)=O)=O)C
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| InChI |
InChI=1S/C37H57N7O14S/c1-24(2)32(34(49)42-27(4-3-11-40-36(38)51)33(48)41-26-7-5-25(6-8-26)23-58-37(52)53)43-30(46)10-14-54-16-18-56-20-21-57-19-17-55-15-12-39-29(45)9-13-44-31(47)22-28(59)35(44)50/h5-8,24,27-28,32,59H,3-4,9-23H2,1-2H3,(H,39,45)(H,41,48)(H,42,49)(H,43,46)(H,52,53)(H3,38,40,51)/t27?,28?,32-/m0/s1
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| InChIKey |
XDGGHYUHKRGJJM-HMELLBQWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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855.965
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Polar area
|
292.35
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Complexity
|
1453.353355
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xlogp Value
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-0.0861
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Heavy Count
|
59
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Rot Bonds
|
30
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Hbond acc
|
14
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker