Linker Information
General Information of This Linker
| Linker ID |
LIN0BODZF
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| Linker Name |
Anti-Her2-LP27 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C84H138N20O28
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(NCCOCCOCCOCCN(CC(NCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)CC(NCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)CCCC2
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| InChI |
InChI=1S/C84H138N20O28/c1-58(2)75(79(115)97-65(10-7-24-91-81(86)117)77(113)95-62-17-13-60(14-18-62)56-131-83(119)93-52-73(109)110)99-69(105)21-31-121-39-42-125-35-27-89-71(107)54-103(29-37-127-45-49-130-48-44-124-34-26-88-64-9-5-6-12-68-67(51-64)101-102-104(68)30-38-128-46-50-129-47-41-123-33-23-85)55-72(108)90-28-36-126-43-40-122-32-22-70(106)100-76(59(3)4)80(116)98-66(11-8-25-92-82(87)118)78(114)96-63-19-15-61(16-20-63)57-132-84(120)94-53-74(111)112/h13-20,58-59,64-66,75-76,88H,5-12,21-57,85H2,1-4H3,(H,89,107)(H,90,108)(H,93,119)(H,94,120)(H,95,113)(H,96,114)(H,97,115)(H,98,116)(H,99,105)(H,100,106)(H,109,110)(H,111,112)(H3,86,91,117)(H3,87,92,118)/t64?,65-,66-,75-,76-/m0/s1
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| InChIKey |
BLDLXCMQUGLZBW-WHXBITIGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1876.14
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Polar area
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658.6
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Complexity
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.
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xlogp Value
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-2.0083
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Heavy Count
|
132
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Rot Bonds
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74
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Hbond acc
|
32
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Hbond Donor
|
18
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Each Antibody-drug Conjugate Related to This Linker