Linker Information
General Information of This Linker
| Linker ID |
LIN0BKLWC
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| Linker Name |
H1H21234N-N297Q- LP12 lINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H68N8O14
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| Isosmiles |
C[C@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(CCC(N1C2=C(C=CC=C2)C3=C(N(N=N3)CCCCCOCCOCCN)C4=C(C1)C=CC=C4)=O)=O)=O)CCC(O)=O)=O)C(O)=O
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| InChI |
InChI=1S/C47H68N8O14/c1-34(47(62)63)50-46(61)38(13-16-43(59)60)51-41(57)17-22-65-26-29-68-31-32-69-30-28-67-24-19-49-40(56)14-15-42(58)54-33-35-9-3-4-10-36(35)45-44(37-11-5-6-12-39(37)54)52-53-55(45)20-7-2-8-21-64-25-27-66-23-18-48/h3-6,9-12,34,38H,2,7-8,13-33,48H2,1H3,(H,49,56)(H,50,61)(H,51,57)(H,59,60)(H,62,63)/t34-,38-/m0/s1
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| InChIKey |
MREIYNMPTXAOJH-UVNLRBHVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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969.103
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Polar area
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294.32
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Complexity
|
1986.467366
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xlogp Value
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1.9127
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Heavy Count
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69
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Rot Bonds
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36
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Hbond acc
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16
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1H21234N-N297Q-LP12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.3 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-4/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References