Linker Information
General Information of This Linker
| Linker ID |
LIN0BKHYU
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| Linker Name |
Ethylmaleimide linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C6H8N2O2
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| Isosmiles |
O=C(N1CCN)C=CC1=O
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| PubChem CID | ||||||
| InChI |
InChI=1S/C6H8N2O2/c7-3-4-8-5(9)1-2-6(8)10/h1-2H,3-4,7H2
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| InChIKey |
ODVRLSOMTXGTMX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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140.142
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Polar area
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63.4
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Complexity
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166.2149912
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xlogp Value
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-1.1299
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Heavy Count
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10
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Rot Bonds
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2
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Hbond acc
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3
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Hbond Donor
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1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
US20250025567A1 ExL5A1 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | > 50% | Positive CLDN6 expression (CLDN6+++/++) | ||
| Method Description |
ExL5A1 was tested in SCID mice that subcutaneously transplanted NUGC33, 3 mg/kg was administeredthrough the tail vein of the tumor-bearing mice.
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| In Vivo Model | NUGC-3 cells SCID mice model | ||||