Linker Information
General Information of This Linker
| Linker ID |
LIN0BJGSR
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| Linker Name |
CN110997010A ADC-3 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C54H74N10O21S2
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| Isosmiles |
CC(C)[C@H](NC(OCCOCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C54H74N10O21S2/c1-31(2)45(61-54(82)84-25-24-83-23-22-62-39(65)17-18-40(62)66)48(75)58-34(10-9-19-56-52(55)80)46(73)57-33-15-13-32(14-16-33)28-85-53(81)60-35(29-86-37-26-41(67)63(49(37)76)20-7-3-5-11-43(69)70)47(74)59-36(51(78)79)30-87-38-27-42(68)64(50(38)77)21-8-4-6-12-44(71)72/h13-18,31,34-38,45H,3-12,19-30H2,1-2H3,(H,57,73)(H,58,75)(H,59,74)(H,60,81)(H,61,82)(H,69,70)(H,71,72)(H,78,79)(H3,55,56,80)/t34-,35?,36?,37?,38?,45-/m0/s1
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| InChIKey |
BQSGADXKSUZZBT-CSIAKXQISA-N
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| Pharmaceutical Properties |
Molecule Weight
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1263.369
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Polar area
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452.35
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Complexity
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2575.230414
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xlogp Value
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0.4264
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Heavy Count
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87
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Rot Bonds
|
40
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Hbond acc
|
20
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker