Linker Information
General Information of This Linker
| Linker ID |
LIN0BEVCU
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| Linker Name |
Linker of ADC2-35
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C71H106N20O26
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@H](CCC(NC2[C@H](O)[C@H](O)[C@@H](C(N(CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)O2)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
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| InChI |
InChI=1S/C71H106N20O26/c1-79(31-46(72)92)53(99)32-80(2)54(100)33-81(3)55(101)34-82(4)56(102)35-83(5)57(103)36-84(6)58(104)37-85(7)59(105)38-86(8)60(106)39-87(9)61(107)40-88(10)62(108)41-89(11)63(109)42-90(12)71(116)67-65(112)66(113)70(117-67)78-48(94)23-22-44(76-47(93)21-17-14-18-26-91-51(97)24-25-52(91)98)68(114)74-28-49(95)73-29-50(96)77-45(69(115)75-30-64(110)111)27-43-19-15-13-16-20-43/h13,15-16,19-20,24-25,44-45,65-67,70,112-113H,14,17-18,21-23,26-42H2,1-12H3,(H2,72,92)(H,73,95)(H,74,114)(H,75,115)(H,76,93)(H,77,96)(H,78,94)(H,110,111)/t44-,45-,65-,66+,67-,70?/m0/s1
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| InChIKey |
IJPKKUWLYCFAAK-KWZMOOJVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1655.743
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Polar area
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585.78
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Complexity
|
3708.160454
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xlogp Value
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-11.5535
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Heavy Count
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117
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Rot Bonds
|
47
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Hbond acc
|
25
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker