Linker Information
General Information of This Linker
| Linker ID |
LIN0BDVRA
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| Linker Name |
Solubilizing group-PEG6-Hypoxia sensitive linker-Azobenzene
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| Linker Type |
Hypoxia sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H52N6O12
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| Isosmiles |
OCC1=CC=C(/N=N/C(C=C2)=CC=C2C(NCCNC(CCOCCOCCOCCOCCOCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O)=O)C=C1
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| InChI |
InChI=1S/C38H52N6O12/c45-29-30-1-5-32(6-2-30)42-43-33-7-3-31(4-8-33)38(50)41-14-13-39-35(47)12-17-51-19-21-53-23-25-55-27-28-56-26-24-54-22-20-52-18-15-40-34(46)11-16-44-36(48)9-10-37(44)49/h1-10,45H,11-29H2,(H,39,47)(H,40,46)(H,41,50)/b43-42+
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| InChIKey |
HRBHDTWHPOQXAD-HBSCQBRPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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784.864
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Polar area
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225.01
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Complexity
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1453.437811
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xlogp Value
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1.3613
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Heavy Count
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56
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Rot Bonds
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31
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Hbond acc
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14
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
aZO-ADC-6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.14 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 0.1 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.39 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to BT474-HDR cells under 0.1 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
16.25 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 toBT474-HDR cells under 20 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
43.77 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 20 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
References