Linker Information
General Information of This Linker
| Linker ID |
LIN0BDRTN
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| Linker Name |
CN113874046B-ADC-4-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C56H80N12O16
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| Isosmiles |
CC([C@H](NC(C1=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2)C=C(NC(CCOCCOCCNC3CCN(CC3)C(CCN4C5=C(C=C4CN(NC)C)C=CC=N5)=O)=O)C=C1)=O)C(N[C@@H](CCCNC(N)=O)C(NC6=CC=C(CO)C=C6)=O)=O)C
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| InChI |
InChI=1S/C56H80N12O16/c1-33(2)45(53(77)64-41(8-6-20-61-56(57)80)52(76)63-37-11-9-34(32-69)10-12-37)65-51(75)40-14-13-38(30-42(40)83-55-48(74)46(72)47(73)49(84-55)54(78)79)62-43(70)18-25-81-27-28-82-26-21-59-36-15-22-67(23-16-36)44(71)17-24-68-39(31-66(4)58-3)29-35-7-5-19-60-50(35)68/h5,7,9-14,19,29-30,33,36,41,45-49,55,58-59,69,72-74H,6,8,15-18,20-28,31-32H2,1-4H3,(H,62,70)(H,63,76)(H,64,77)(H,65,75)(H,78,79)(H3,57,61,80)/t41-,45-,46-,47-,48+,49-,55+/m0/s1
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| InChIKey |
LANPMUAQTATTEF-FMFPWLBZSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1177.324
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Polar area
|
392.09
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Complexity
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2727.856174
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xlogp Value
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-0.2751
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Heavy Count
|
84
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Rot Bonds
|
32
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Hbond acc
|
20
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker