Linker Information
General Information of This Linker
| Linker ID |
LIN0AZOHM
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| Linker Name |
Maleimidyl- (CH2)5-Val-Cit-pAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C28H40N6O7
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| Isosmiles |
CC([C@H](NC(CCCCCN(C1=O)C(C=C1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| InChI |
InChI=1S/C28H40N6O7/c1-18(2)25(33-22(36)8-4-3-5-16-34-23(37)13-14-24(34)38)27(40)32-21(7-6-15-30-28(29)41)26(39)31-20-11-9-19(17-35)10-12-20/h9-14,18,21,25,35H,3-8,15-17H2,1-2H3,(H,31,39)(H,32,40)(H,33,36)(H3,29,30,41)/t21-,25-/m0/s1
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| InChIKey |
AMKBTTRWLGVRER-OFVILXPXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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572.663
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Polar area
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200.03
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Complexity
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1051.539999
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xlogp Value
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0.6769
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Heavy Count
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41
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Rot Bonds
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17
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Hbond acc
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7
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||
MORAb-003 ADC9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
253 nM
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High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||