Linker Information
General Information of This Linker
| Linker ID |
LIN0AZEFA
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| Linker Name |
D3 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C77H134N14O26
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| Isosmiles |
CC(C)[C@H](NC(CCC(NC([C@@H](NC(CON)=O)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)CN[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)=O)C(N[C@H](C(NC2=CC=C(C=C2)CO)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C77H134N14O26/c1-56(2)69(74(100)89-64(11-8-25-82-76(78)102)72(98)85-60-17-13-58(53-92)14-18-60)84-52-62(21-22-67(95)91-70(57(3)4)75(101)90-65(12-9-26-83-77(79)103)73(99)86-61-19-15-59(54-93)16-20-61)87-71(97)63(88-68(96)55-117-80)10-6-7-24-81-66(94)23-27-105-30-31-107-34-35-109-38-39-111-42-43-113-46-47-115-50-51-116-49-48-114-45-44-112-41-40-110-37-36-108-33-32-106-29-28-104-5/h13-20,56-57,62-65,69-70,84,92-93H,6-12,21-55,80H2,1-5H3,(H,81,94)(H,85,98)(H,86,99)(H,87,97)(H,88,96)(H,89,100)(H,90,101)(H,91,95)(H3,78,82,102)(H3,79,83,103)/t62?,63-,64-,65-,69-,70-/m0/s1
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| InChIKey |
IEZVUKSVMQAMKD-CHLBHNJCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1671.991
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Polar area
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550.77
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Complexity
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2847.070792
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xlogp Value
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-0.9677
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Heavy Count
|
117
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Rot Bonds
|
76
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Hbond acc
|
28
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker