Linker Information
General Information of This Linker
| Linker ID |
LIN0AXFDU
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| Linker Name |
MC-Val-Ala-RG-13
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C46H64N8O11
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| Isosmiles |
O=C(N[C@@H](C)C(NC1=CC=C(COC(NCC2=CC=CC=C2N(CCN3CCN(CCCC(OCC)=O)CC3)C(O)=O)=O)C=C1)=O)[C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O
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| InChI |
InChI=1S/C46H64N8O11/c1-5-64-41(58)15-11-22-51-24-26-52(27-25-51)28-29-53(46(62)63)37-13-9-8-12-35(37)30-47-45(61)65-31-34-16-18-36(19-17-34)49-43(59)33(4)48-44(60)42(32(2)3)50-38(55)14-7-6-10-23-54-39(56)20-21-40(54)57/h8-9,12-13,16-21,32-33,42H,5-7,10-11,14-15,22-31H2,1-4H3,(H,47,61)(H,48,60)(H,49,59)(H,50,55)(H,62,63)/t33-,42-/m0/s1
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| InChIKey |
IQMSBABCDCVOIK-OFDVDTBYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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905.063
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Polar area
|
236.33
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Complexity
|
1891.28394
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xlogp Value
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3.6277
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Heavy Count
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65
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Rot Bonds
|
25
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Hbond acc
|
12
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker