Linker Information
General Information of This Linker
| Linker ID |
LIN0AVMXM
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Pentaglycine-EDA (Non-cleavable)
|
|||||
| Antibody-Linker Relation |
Uncleavable
|
|||||
| Structure |
|
|||||
| Formula |
C30H48N10O10
|
|||||
| Isosmiles |
CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)N(C)CCN(C)C(=O)O)cc1
|
|||||
| InChI |
InChI=1S/C30H48N10O10/c1-18(2)25(38-24(43)16-35-23(42)15-34-22(41)14-31)27(45)37-21(6-5-11-33-28(32)46)26(44)36-20-9-7-19(8-10-20)17-50-30(49)40(4)13-12-39(3)29(47)48/h7-10,18,21,25H,5-6,11-17,31H2,1-4H3,(H,34,41)(H,35,42)(H,36,44)(H,37,45)(H,38,43)(H,47,48)(H3,32,33,46)/t21-,25-/m0/s1
|
|||||
| InChIKey |
PJLSJAJXZHXPQD-OFVILXPXSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
708.774
|
Polar area
|
296.72
|
||
|
Complexity
|
708.3554877
|
xlogp Value
|
-1.9315
|
|||
|
Heavy Count
|
50
|
Rot Bonds
|
20
|
|||
|
Hbond acc
|
10
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
SOT-102 [Phase 1/2 (Terminated)]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT05525286 | Clinical Status | Phase 1 | ||
| Clinical Description |
A multicentric phase 1/2 trial to evaluate the safety and efficacy of SOT102 as monotherapy and in combination with standard of care treatment in patients with gastric and pancreatic adenocarcinoma.
|
||||
References