Linker Information
General Information of This Linker
| Linker ID |
LIN0AVHMB
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| Linker Name |
Linker of ADC2-50
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H50N8O17S
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)[C@@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)CCC(NC[C@H](O2)[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)=O.[S]
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| InChI |
InChI=1S/C36H50N8O17.S/c45-18-23-33(57)34(58)32(56)22(61-23)13-38-24(46)7-6-20(43-26(48)10-11-37-27(49)14-39-25(47)8-9-30(52)53)35(59)41-15-28(50)40-16-29(51)44-21(36(60)42-17-31(54)55)12-19-4-2-1-3-5-19;/h1-5,8-9,20-23,32-34,45,56-58H,6-7,10-18H2,(H,37,49)(H,38,46)(H,39,47)(H,40,50)(H,41,59)(H,42,60)(H,43,48)(H,44,51)(H,52,53)(H,54,55);/b9-8-;/t20-,21-,22-,23+,32-,33+,34+;/m0./s1
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| InChIKey |
RSVUIUNNOMJQMD-KNDZGZDJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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898.902
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Polar area
|
397.55
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Complexity
|
1662.627513
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xlogp Value
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-6.7178
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Heavy Count
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62
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Rot Bonds
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25
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Hbond acc
|
15
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker