General Information of This Linker (ID: LIN0AUVJY)
Name
MC
Antibody-Linker Relation
Uncleavable
Structure
Isosmiles
O=C(O)CCCCCN1C(=O)C=CC1=O
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
αCD38-MC-I034 [Investigative]
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.022 nM
In Vitro Model Plasma cell myeloma NCI-H929 cells CVCL_1600
αBCMA-MC-I034 [Investigative]
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.046 nM
In Vitro Model Plasma cell myeloma NCI-H929 cells CVCL_1600
References
Ref 1 Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy