Linker Information
General Information of This Linker
| Linker ID |
LIN0APWTQ
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| Linker Name |
DIBAC-GGG- linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C25H25N5O5
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| Isosmiles |
O=C(N)CNC(CNC(CNC(CCC(N(C(C=CC=C1)=C1C#C2)CC3=C2C=CC=C3)=O)=O)=O)=O
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| InChI |
InChI=1S/C25H25N5O5/c26-21(31)13-27-23(33)15-29-24(34)14-28-22(32)11-12-25(35)30-16-19-7-2-1-5-17(19)9-10-18-6-3-4-8-20(18)30/h1-8H,11-16H2,(H2,26,31)(H,27,33)(H,28,32)(H,29,34)
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| InChIKey |
HIXQZVJXXKTSOG-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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475.505
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Polar area
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150.7
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Complexity
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1173.759299
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xlogp Value
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-0.4529
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Heavy Count
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35
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Rot Bonds
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9
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Hbond acc
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5
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP13-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.078 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 39% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||