Linker Information
General Information of This Linker
| Linker ID |
LIN0AOZNI
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| Linker Name |
CN119317630A ADC-C11 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C19H31N5O9
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| Isosmiles |
CC([C@H](NC(CCNC(CNC(CCC(O)=O)=O)=O)=O)C(N[C@@H](C)C(NCC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C19H31N5O9/c1-10(2)17(19(33)23-11(3)18(32)22-9-16(30)31)24-13(26)6-7-20-14(27)8-21-12(25)4-5-15(28)29/h10-11,17H,4-9H2,1-3H3,(H,20,27)(H,21,25)(H,22,32)(H,23,33)(H,24,26)(H,28,29)(H,30,31)/t11-,17-/m0/s1
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| InChIKey |
NHGDPNUUYKFIPN-GTNSWQLSSA-N
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| Pharmaceutical Properties |
Molecule Weight
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473.483
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Polar area
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220.1
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Complexity
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708.3203425
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xlogp Value
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-2.68
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Heavy Count
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33
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Rot Bonds
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15
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Hbond acc
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7
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN119317630A ADC-C11 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
72 nM
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| Method Description |
Distribute the cell lines H358 (1E3/well), to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
94 nM
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| Method Description |
Distribute the cell lines H1048 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
100 nM
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| Method Description |
Distribute the cell lines H441 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||