Linker Information
General Information of This Linker
| Linker ID |
LIN0AJUQX
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| Linker Name |
Linker of ADC2-49
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C48H69N13O20
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| Isosmiles |
CN(CC(N(C)CC(N(CC(N(C)CC(N)=O)=O)C)=O)=O)C(C[C@H]1[C@H](O)[C@H](O)[C@H](O1)CNC(CC[C@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C48H69N13O20/c1-58(23-32(49)62)40(70)25-60(3)42(72)26-61(4)41(71)24-59(2)39(69)17-30-45(77)46(78)31(81-30)18-51-33(63)11-10-28(56-35(65)14-15-50-36(66)19-52-34(64)12-13-43(73)74)47(79)54-20-37(67)53-21-38(68)57-29(48(80)55-22-44(75)76)16-27-8-6-5-7-9-27/h5-9,12-13,28-31,45-46,77-78H,10-11,14-26H2,1-4H3,(H2,49,62)(H,50,66)(H,51,63)(H,52,64)(H,53,67)(H,54,79)(H,55,80)(H,56,65)(H,57,68)(H,73,74)(H,75,76)/b13-12-/t28-,29-,30-,31+,45-,46+/m0/s1
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| InChIKey |
BNKAPUBDVGHYOE-UJCOUNKXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1148.151
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Polar area
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481.42
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Complexity
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2386.786644
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xlogp Value
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-9.0102
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Heavy Count
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81
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Rot Bonds
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34
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Hbond acc
|
18
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker