Linker Information
General Information of This Linker
| Linker ID |
LIN0AGAQL
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| Linker Name |
Linker of ADC2-29
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H49N7O15
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)CCC(NC[C@@H](O3)[C@@H](O)[C@@H](O)[C@@H]3CC(O)=O)=O
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| InChI |
InChI=1S/C37H49N7O15/c45-26(38-17-25-35(56)34(55)24(59-25)16-32(51)52)11-10-22(42-27(46)9-5-2-6-14-44-30(49)12-13-31(44)50)36(57)40-18-28(47)39-19-29(48)43-23(37(58)41-20-33(53)54)15-21-7-3-1-4-8-21/h1,3-4,7-8,12-13,22-25,34-35,55-56H,2,5-6,9-11,14-20H2,(H,38,45)(H,39,47)(H,40,57)(H,41,58)(H,42,46)(H,43,48)(H,51,52)(H,53,54)/t22-,23-,24-,25+,34-,35+/m0/s1
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| InChIKey |
WLZAFEZYDNSRRR-ZUJRIHCJSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
831.833
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Polar area
|
336.27
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Complexity
|
1646.627513
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xlogp Value
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-4.0224
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Heavy Count
|
59
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Rot Bonds
|
25
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Hbond acc
|
13
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker