Linker Information
General Information of This Linker
| Linker ID |
LIN0ACVXN
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| Linker Name |
Linker of ADC2-7-2
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H51N9O15
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCNC(CN1C(C=CC1=O)=O)=O)=O)CCC(NC(O2)[C@H](O)[C@H](O)[C@H]2C(O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
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| InChI |
InChI=1S/C37H51N9O15/c1-18(2)28(34(57)43-21(4-3-14-40-37(38)60)32(55)41-20-7-5-19(17-47)6-8-20)45-33(56)22(9-10-23(48)44-35-30(54)29(53)31(61-35)36(58)59)42-24(49)13-15-39-25(50)16-46-26(51)11-12-27(46)52/h5-8,11-12,18,21-22,28-31,35,47,53-54H,3-4,9-10,13-17H2,1-2H3,(H,39,50)(H,41,55)(H,42,49)(H,43,57)(H,44,48)(H,45,56)(H,58,59)(H3,38,40,60)/t21-,22-,28-,29-,30+,31-,35?/m0/s1
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| InChIKey |
VGHKYMTUHLDVJH-PDRZNVHOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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861.863
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Polar area
|
374.32
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Complexity
|
1741.149528
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xlogp Value
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-4.4647
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Heavy Count
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61
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Rot Bonds
|
23
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Hbond acc
|
14
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker