Linker Information
General Information of This Linker
| Linker ID |
LIN0ABFMB
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|---|---|---|---|---|---|---|
| Linker Name |
WO2023173026A1-ADC-L079-040-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H55N7O12
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| Isosmiles |
CC(C)[C@H](NC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C36H55N7O12/c1-25(2)33(35(50)41-28(4-3-13-39-36(37)51)34(49)40-27-7-5-26(24-44)6-8-27)42-30(46)12-16-52-18-20-54-22-23-55-21-19-53-17-14-38-29(45)11-15-43-31(47)9-10-32(43)48/h5-10,25,28,33,44H,3-4,11-24H2,1-2H3,(H,38,45)(H,40,49)(H,41,50)(H,42,46)(H3,37,39,51)/t28-,33+/m1/s1
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| InChIKey |
PEGLOOGTSQEDBL-YDYNHKSESA-N
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| Pharmaceutical Properties |
Molecule Weight
|
777.873
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Polar area
|
266.05
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Complexity
|
1336.864752
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xlogp Value
|
-0.9207
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Heavy Count
|
55
|
Rot Bonds
|
29
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Hbond acc
|
12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker