Antibody Information

General Information of This Antibody

Antibody ID	ANI0VIBRC
Antibody Name	Anti-ENPP1 IgG1 17
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

MMAE-IgG1 17 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.00 nM-10.00 nM	Positive ENPP1 expression (ENPP1 +++/++)
Method Description	For the cell-killing activity of ADC,293T, 293T-ENPP1, and HepG2 cells were seeded at 2000 cells/well in 96-well white plate and incubated in cell growth medium overnight at 37°C in 5%CO₂.
In Vitro Model	Hepatoma	HEK293T cells (ENPP1 expression)		CVCL_0063
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	65.00 nM	Positive ENPP1 expression (ENPP1 +++/++)
Method Description	For the cell-killing activity of ADC,293T, 293T-ENPP1, and HepG2 cells were seeded at 2000 cells/well in 96-well white plate and incubated in cell growth medium overnight at 37°C in 5%CO₂.
In Vitro Model	Hepatoblastoma	Hep-G2 cells		CVCL_0027
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	> 100 nM	Negative ENPP1 expression (ENPP1-)
Method Description	For the cell-killing activity of ADC,293T, 293T-ENPP1, and HepG2 cells were seeded at 2000 cells/well in 96-well white plate and incubated in cell growth medium overnight at 37°C in 5%CO₂.
In Vitro Model	Normal	HEK293T cells		CVCL_0063

References

Ref 1	Human antibodies targeting ENPP1 as candidate therapeutics for cancers. Front Immunol. 2023 Jan 25;14:1070492. doi: 10.3389/fimmu.2023.1070492. eCollection 2023.