Antibody Information

General Information of This Antibody

Antibody ID	ANI0MVXLB
Antibody Name	Anti-RON Zt/g4 (IgG1 kappa)
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Macrophage-stimulating protein receptor (MST1R)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

Zt/g4-MMAE [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 100.00% (Day 40)	Positive RON expression (RON +++/++)
Method Description	Treatment began when tumors reached a mean tumor volume of 100 to 150 mm³. Zt/g4-MMAE or Zt/g4-DM1 at 20 mg/kg in a Q12 2 regimen was injected through the tail vein.
In Vivo Model	BxPC3 CDX model
In Vitro Model	Pancreatic ductal adenocarcinoma	BxPC-3 cells		CVCL_0186

References

Ref 1	Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase. Mol Pharm. 2018 Aug 6;15(8):3260-3271. doi: 10.1021/acs.molpharmaceut.8b00298. Epub 2018 Jun 26.

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