Antibody Information

General Information of This Antibody
Antibody ID
ANI0MPIRZ
Antibody Name
A5/158
Synonyms
A5-158
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Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1-kappa
Antigen Name
C-type mannose receptor 2 (MRC2)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
A5/158-vc-MMAE [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 91.20% (Day 32) Positive MRC2 expression (MRC2 +++/++)
Method Description
Vehicle (PBS) or 10 mg/kg of A5/158-vc-MMAE were administered into the lateral tail vein of mice twice a week for 2 weeks. Primary tumors were weighed at necropsy.
In Vivo Model MG-63-mChLuc2 CDX model
In Vitro Model Osteosarcoma MG-63 cells CVCL_0426
References
Ref 1 Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma. Mol Cancer Ther. 2023 Feb 1;22(2):240-253. doi: 10.1158/1535-7163.MCT-22-0312.

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