Antibody Information
General Information of This Antibody
| Antibody ID | ANI0LRCNY |
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|---|---|---|---|---|---|---|
| Antibody Name | GABRP-Ab |
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| Antibody Type | polyclonal antibody (PAB) |
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| Antigen Name | Gamma-aminobutyric acid receptor subunit pi (GABRP) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
GABRP Ab-DM1 ADC [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
100 ng/mL - 500 ng/mL
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Positive GABRP expression (GABRP+++/++) | ||
| Method Description |
Cells were plated at 2000 cells/well in triplicate in 96-well plates and exposed to GABRP Ab-DM1 ADC and control IgG-DM1 for 3 days.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
100 ng/mL - 500 ng/mL
|
Positive GABRP expression (GABRP+++/++) | ||
| Method Description |
Cells were plated at 2000 cells/well in triplicate in 96-well plates and exposed to GABRP Ab-DM1 ADC and control IgG-DM1 for 3 days.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 500 ng/mL | Positive GABRP expression (GABRP+++/++) | ||
| Method Description |
Cells were plated at 2000 cells/well in triplicate in 96-well plates and exposed to GABRP Ab-DM1 ADC and control IgG-DM1 for 3 days.
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| In Vitro Model | Breast ductal carcinoma | HCC1143 cells | CVCL_1245 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 500 ng/mL | Positive GABRP expression (GABRP+++/++) | ||
| Method Description |
Cells were plated at 2000 cells/well in triplicate in 96-well plates and exposed to GABRP Ab-DM1 ADC and control IgG-DM1 for 3 days.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cells | CVCL_0062 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 500 ng/mL | Positive GABRP expression (GABRP+++/++) | ||
| Method Description |
Cells were plated at 2000 cells/well in triplicate in 96-well plates and exposed to GABRP Ab-DM1 ADC and control IgG-DM1 for 3 days.
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
References
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