Antibody Information

General Information of This Antibody

Antibody ID	ANI0KTMBU
Antibody Name	Anti-DLA-DR mAb B5
Antibody Type	Monoclonal antibody (mAb)
Antigen Name	Dog leukocyte antigen DR (DLA-DR)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

B5-MTX [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	5.00 nM	Positive DLA-DR expression (DLA-DR+++/++)
Method Description	For in vitro cytotoxicity assays, 1.25 x 10⁵ cells were seeded on a 24-well plate. The cells were preincubated for 2 h with 20 M ZVAD. Then, 2 ug/mL of B5 or B5-MTX were added to the cells.
In Vitro Model	Canine lymphoma	CLBL-1 cells		CVCL_L322

References

Ref 1	An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma. Cancers (Basel). 2019 Sep 26;11(10):1438. doi: 10.3390/cancers11101438.

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