Antibody Information

General Information of This Antibody

Antibody ID	ANI0DRDKF
Antibody Name	Anti-EDB Ab cot
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Vesicle-associated membrane protein 8 (VAMP8)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

cot-APTEDB-SN38 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 22.20% (Day 8)	Positive EDB expression (EDB +++/++)
Method Description	BALB/c nude mice bearing U87MG tumors (450 mm³) were injected intravenously via the tail vein with Abcot (10 mg/kg) or cot-APTEDB-SN38 (equivalent to 2 mg SN38/kg).
In Vivo Model	U87MG CDX model
In Vitro Model	Glioblastoma	U-87MG cells		CVCL_0022

References

Ref 1	Antibody-Assisted Delivery of a Peptide-Drug Conjugate for Targeted Cancer Therapy. Mol Pharm. 2019 Jan 7;16(1):165-172. doi: 10.1021/acs.molpharmaceut.8b00924. Epub 2018 Dec 17.

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