Antibody Information

General Information of This Antibody
Antibody ID
ANI0DEHSE
Antibody Name
Septuximab
Synonyms
FZD7
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Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Chimeric IgG1-kappa
Antigen Name
Frizzled-7 (FZD7)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Septuximab vedotin [Clinical candidate]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 5 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.03 nM
Positive FZD7 expression (FZD7+++/++)
Method Description
Cells were seeded in a 96-well plate the day before drug treatment. MA-148, PA-1, and MA-148 FZD7-KO were incubated with the indicated drugs for 3 days.
In Vitro Model Ovarian serous adenocarcinoma OVCAR-3 cells (FZD7 overexpression) CVCL_0465
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
5.00 nM
Positive FZD7 expression (FZD7+++/++)
Method Description
Cells were seeded in a 96-well plate the day before drug treatment. MA-148, PA-1, and MA-148 FZD7-KO were incubated with the indicated drugs for 3 days.
In Vitro Model Ovarian cystadenocarcinoma MA148 cells CVCL_AK47
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
5.00 nM
Positive FZD7 expression (FZD7+++/++)
Method Description
Cells were seeded in a 96-well plate the day before drug treatment. MA-148, PA-1, and MA-148 FZD7-KO were incubated with the indicated drugs for 3 days.
In Vitro Model Ovarian mixed germ cell tumor PA-1 cells CVCL_0479
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
25.00 nM
Negative FZD7 expression (FZD7-)
Method Description
Cells were seeded in a 96-well plate the day before drug treatment. MA-148, PA-1, and MA-148 FZD7-KO were incubated with the indicated drugs for 3 days.
In Vitro Model Ovarian serous adenocarcinoma OVCAR-3 cells CVCL_0465
Experiment 5 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
60.00 nM
Negative FZD7 expression (FZD7-)
Method Description
Cells were seeded in a 96-well plate the day before drug treatment. MA-148, PA-1, and MA-148 FZD7-KO were incubated with the indicated drugs for 3 days.
In Vitro Model Ovarian cystadenocarcinoma MA148 cells (FZD7 knock-out) CVCL_AK47
References
Ref 1 A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022 Jan;21(1):113-124.

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