Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ZKVNP
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| ADC Name |
HPS157-039-004
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| Synonyms |
HPS157 039 004
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| Organization |
Oncomatryx Biopharma SL
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Fibrosarcoma [ICD11:2B53]
Investigative
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| Drug-to-Antibody Ratio |
4.1
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| Antibody Name |
FAP hu36
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Antibody Info | ||||
| Antigen Name |
Prolyl endopeptidase FAP (FAP)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
HPS157-039-004 linker
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General Information of The Activity Data Related to This ADC
Discovered Using Patient-derived Xenograft Model
| Standard Type | Value | Units | Animal Model (No. of PDX) |
|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 70
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%
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Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
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Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) |
90
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nM
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CVCL_0317
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Fibrosarcoma
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| Half Maximal Inhibitory Concentration (IC50) |
108
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nM
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CVCL_0317
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Fibrosarcoma
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 70.00% (Day 33) | Positive FAP expression (FAP+++/++) | ||
| Method Description |
Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
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| In Vivo Model | Pancreatic adenocarcinoma PDX model (PDX: PAXF-736) | ||||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 90.00 nM | Positive FAP expression (FAP+++/++) | ||
| Method Description |
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
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| In Vitro Model | Fibrosarcoma | HT-1080 cells (FAP expression) | CVCL_0317 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 108.00 nM | Negative FAP expression (FAP-) | ||
| Method Description |
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
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| In Vitro Model | Fibrosarcoma | HT-1080 cells (FAP expression) | CVCL_0317 | ||
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