Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0YNODF
ADC Name
KA-3123-LD38
Synonyms
KA-3123-LD38
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Organization
Kyinno Biotechnology Co., Ltd.; Shanghai Escugen Biotechnology Co., Ltd.
Drug Status
Investigative
Antibody Name
undisclosed
Antigen Name
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
  Antigen Info 
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
Undisclosed
Combination Type
LD38
ADC-specific functional property(2027 Update)
Binding Affinity
Click To Hide/Show 2 ADC-specific functional property Data
Dissocation Constant (Kd) Binding Target Description Reference
<0.01 nM
B7H3
KA-3123-LD38 binds to B7H3 with high affinity, with a Kd of less than 0.01 nM, while its affinity for EGFR is weaker, with a Kd greater than 10 nM.
[1]
>10 nM
EGFR
KA-3123-LD38 binds to B7H3 with high affinity, with a Kd of less than 0.01 nM, while its affinity for EGFR is weaker, with a Kd greater than 10 nM.
[1]
References
Ref 1 KA-3123-LD38: a novel bispecific antibody-drug conjugate (ADC) targeting EGFR and B7H3 with a DNA topoisomerase I inhibitor payload