Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0XGHTG
ADC Name
HPS157-039-001
Synonyms
HPS157 039 001
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Organization
Oncomatryx Biopharma SL
Drug Status
Investigative
Drug-to-Antibody Ratio
3.38
Antibody Name
FAP hu36
  Antibody Info 
Antigen Name
Prolyl endopeptidase FAP (FAP)
  Antigen Info 
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
HPS157-039-001 linker
General Information of The Activity Data Related to This ADC
Discovered Using Patient-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Animal Model (No. of PDX)
Tumor Growth Inhibition value (TGI) 
≈ 0
%
Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Tumor Growth Inhibition value (TGI) 
≈ 0
%
Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
5.6
nM
CVCL_0317
Fibrosarcoma
Half Maximal Inhibitory Concentration (IC50) 
10.33
nM
CVCL_0317
Fibrosarcoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Patient-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 0% Negative FAP expression (FAP-)
Method Description
Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
In Vivo Model Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 0% Negative FAP expression (FAP-)
Method Description
Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
In Vivo Model Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 5.6 nM Positive FAP expression (FAP+++/++)
Method Description
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model Fibrosarcoma HT-1080 cells (FAP expression) CVCL_0317
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 10.33 nM Negative FAP expression (FAP-)
Method Description
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model Fibrosarcoma HT-1080 cells (FAP expression) CVCL_0317
References
Ref 1 Antibody-drug conjugates and immunotoxins.