Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0XGHTG
ADC Name
HPS157-039-001
Synonyms
HPS157 039 001
   Click to Show/Hide
Organization
Oncomatryx Biopharma SL
Drug Status
Investigative
Indication
In total 1 Indication(s)
Fibrosarcoma [ICD11:2B53]
Investigative
Drug-to-Antibody Ratio
3.38
Antibody Name
FAP hu36
  Antibody Info 
Antigen Name
Prolyl endopeptidase FAP (FAP)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
HPS157-039-001 linker
General Information of The Activity Data Related to This ADC
Discovered Using Patient-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Animal Model (No. of PDX)
Tumor Growth Inhibition value (TGI) 
≈ 0
%
Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Tumor Growth Inhibition value (TGI) 
≈ 0
%
Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Inhibitory Concentration (IC50) 
5.6
nM
CVCL_0317
Fibrosarcoma
Half Maximal Inhibitory Concentration (IC50) 
10.33
nM
CVCL_0317
Fibrosarcoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Patient-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 0.00% Negative FAP expression (FAP-)
Method Description
Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
In Vivo Model Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 0.00% Negative FAP expression (FAP-)
Method Description
Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
In Vivo Model Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 5.60 nM Positive FAP expression (FAP+++/++)
Method Description
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model Fibrosarcoma HT-1080 cells (FAP expression) CVCL_0317
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) 10.33 nM Negative FAP expression (FAP-)
Method Description
Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model Fibrosarcoma HT-1080 cells (FAP expression) CVCL_0317
References
Ref 1 Antibody-drug conjugates and immunotoxins.

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