Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WIROI
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| ADC Name |
uS11998611B2 Ex.32
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| Synonyms |
Ex.32
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| Organization |
Cryptophycin antibody conjugates for the treatment of cancer
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.9
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| Antibody Name |
hu2H11_R35-74
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Antibody Info | Antigen Name |
Undisclosed
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| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The ADMET Data Related to This ADC(2027 Update)
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Elimination Half-Life (t1/2) | 2 | h |
By Cathepsin BDrug release by Cathepsin B was evaluated in vitro by incubating the ADC (1.5 ug/mL) in the presence of human Cathepsin B (Calbiochem #219362, 40 ug/mL) in acetate buffer pH 5 at 37°C. for 24 h and detecting the drug by UPLC-MS-SIR-DAD-ELSD. The slope was determined based on the kinetics over the 1st hour, the half-life on the 24 h kinetics.
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