Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0VDWJS
ADC Name
TMB-355-ADC
Synonyms
TMB-355-ADC
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Organization
TAIMED BIOLOGICS INC.
Drug Status
Investigative
Structure
Antibody Name
Ibalizumab
  Antibody Info 
Antigen Name
T-cell surface glycoprotein CD4 (CD4)
  Antigen Info 
Payload Name
TMB-355-ADC Payload
  Payload Info 
Linker Name
TMB-355-ADC Linker
  Linker Info 
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
4.1
nM
CVCL_1179
Diffuse large B-cell lymphoma germinal center B-cell type
Half Maximal inhibitory Concentration (lC50) 
49.9
nM
CVCL_1179
Diffuse large B-cell lymphoma germinal center B-cell type
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 4.1 nM Positive CD4 expression (CD4+++/++)
Method Description
A certain number of DoHH2 cells in the logarithmic growth phase were seeded into a 96-well culture plate, and drugs at different concentrations were added to the culture plate for reaction for 72 h. After the reaction was completed, an MTT working solution was added for reaction for 6h, then blue-purple crystalline formazan was dissolved with atriplex solution.

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In Vitro Model Diffuse large B-cell lymphoma germinal center B-cell type DoHH2 cells CVCL_1179
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 49.9 nM Positive CD4 expression (CD4+++/++)
Method Description
A certain number of DoHH2 cells in the logarithmic growth phase were seeded into a 96-well culture plate, and drugs at different concentrations were added to the culture plate for reaction for 72 h. After the reaction was completed, an MTT working solution was added for reaction for 6h, then blue-purple crystalline formazan was dissolved with atriplex solution.

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In Vitro Model Diffuse large B-cell lymphoma germinal center B-cell type DoHH2 cells CVCL_1179
References
Ref 1 Antibody-drug conjugates for treating infections of human immunodeficiency virus (HIV)