Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0UMZIX
ADC Name
40037092 ADC-1
Synonyms
ADC-1
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Organization
Takeda Development Center Americas Inc.
Drug Status
Investigative
Antibody Name
a therapeutic human IgG4 mAb
  Antibody Info 
Antigen Name
Undisclosed
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
Undisclosed
General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
Click To Hide/Show 1 Absorption Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 11904±2846 h&#42nmol/L
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg, AUClast.
 [1]
Distribution
Click To Hide/Show 2 Distribution Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 11904±2846 h&#42nmol/L
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg, AUClast.
 [1]
Volume of Distribution (Vd) 111±15 mL/kg
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg.
 [1]
Metabolism
Click To Hide/Show 1 Metabolism Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 11904±2846 h&#42nmol/L
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg, AUClast.
 [1]
Excretion
Click To Hide/Show 3 Excretion Data Related to This Level
Standard Type Value Units Description Reference
Elimination Half-Life (t1/2) 39±3 h
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg.
 [1]
Area Under the Concentration-Time Curve (AUC) 11904±2846 h&#42nmol/L
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg, AUClast.
 [1]
Clearance (CL) 2.7±0.6 mL/h/kg
The parameter of conjugate payload for ADC-1 and ADC-2 after a single intravenous administration at doses of 1.5 mg/kg.
 [1]
References
Ref 1 Detection of antidrug antibodies against antibody-drug conjugates by solid-phase extraction with acid dissociation in cynomolgus monkey serum