Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0SONBG
ADC Name	HPS157-039-005
Synonyms	HPS157 039 005 Click to Show/Hide
Organization	Oncomatryx Biopharma SL
Drug Status	Investigative
Indication	In total 1 Indication(s) Fibrosarcoma [ICD11:2B53] Investigative
Drug-to-Antibody Ratio	3.92
	3D MOL	2D MOL
Antibody Name	FAP hu36		Antibody Info
Antigen Name	Prolyl endopeptidase FAP (FAP)		Antigen Info
Payload Name	Undisclosed
Linker Name	HPS157-039-005 linker

General Information of The Activity Data Related to This ADC

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Standard Type	Value	Units	Animal Model (No. of PDX)
Tumor Growth Inhibition value (TGI)	≈ 20	%	Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.96	nM	CVCL_0317	Fibrosarcoma
Half Maximal Inhibitory Concentration (IC50)	555	nM	CVCL_0317	Fibrosarcoma

Full List of Activity Data of This Antibody-drug Conjugate

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 20.00% (Day 33)	Positive FAP expression (FAP+++/++)
Method Description	Mice were treated with an intravenous dose of the ADCs at 2.5 mg/kg, qw*1.
In Vivo Model	Pancreatic adenocarcinoma PDX model (PDX: PAXF-736)

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.96 nM	Negative FAP expression (FAP-)
Method Description	Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model	Fibrosarcoma	HT-1080 cells (FAP expression)		CVCL_0317
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	555.00 nM	Positive FAP expression (FAP+++/++)
Method Description	Cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
In Vitro Model	Fibrosarcoma	HT-1080 cells (FAP expression)		CVCL_0317

References

Ref 1	Antibody-drug conjugates and immunotoxins.