General Information of This Antibody-drug Conjugate (ID: DRG0PUNUP)
ADC Name
SHR-4597
Synonyms
SHR-4597
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Organization
Jiangsu Hengrui Pharmaceuticals (Originator)
Drug Status
Phase 2
Drug-to-Antibody Ratio
1.43
Structure
Antibody Name
Anti-IL-4Rα antibody
 Antibody Info 
Antigen Name
Interleukin-4 receptor subunit alpha isoform 2 precursor
 Antigen Info 
Payload Name
Budesonide
 Payload Info 
Payload Target
Glucocorticoid receptor (NR3C1)
 Target Info 
Linker Name
Mc-PEG3-Gly-Gly-Phe-Gly
 Linker Info 
Conjugate Type
Random Cysteines
2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
Disease Name Phase 1 Phase 2 Phase 3 Approved
Asthma
1 Trials
Clinical trial identifier
NCT06385964; CTR20241449
1 Trials
Clinical trial identifier
NCT06940700; CTR20251590