Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0LDOOO
ADC Name	hz1613F12-G-13
Synonyms	hz1613F12 G-13 Click to Show/Hide
Organization	Pierre Fabre SA.
Drug Status	Investigative
Indication	In total 1 Indication(s) Renal cell carcinoma [ICD11:2C90] Investigative
Drug-to-Antibody Ratio	4
	3D MOL	2D MOL
Antibody Name	hz1613F12		Antibody Info
Antigen Name	Tyrosine-protein kinase receptor UFO (AXL)		Antigen Info
Payload Name	Undisclosed
Linker Name	hz1613F12-G-13 linker
Conjugate Type	Random conjugation through reduced inter-chain cysteines.

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.14	nM	CVCL_1705	Renal cell carcinoma
Half Maximal Inhibitory Concentration (IC50)	> 10	nM	CVCL_0031	Invasive breast carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.14 nM	Positive AXL expression (AXL+++/++)
Method Description	Briefly, cells were seeded into 96 well multi-well plates the day before drug treatment at 2500 cells per well. ADCs and controls were serially diluted and then added to the mw-96 plates. Cells were then incubated for 6 days at 37°C and 5% CO₂.
In Vitro Model	Renal cell carcinoma	SN12C cells		CVCL_1705
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	> 10.00 nM	Negative AXL expression (AXL-)
Method Description	Briefly, cells were seeded into 96 well multi-well plates the day before drug treatment at 2500 cells per well. ADCs and controls were serially diluted and then added to the mw-96 plates. Cells were then incubated for 6 days at 37°C and 5% CO₂.
In Vitro Model	Invasive breast carcinoma	MCF-7 cells		CVCL_0031

References

Ref 1	Antibody-drug-conjugate and its use for the treatment of cancer.