Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0KPJEU
ADC Name
39948340 ADC 3 (nobinding)
Synonyms
ADC 3 (nobinding)
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Organization
Bristol-Myers Squibb.
Drug Status
Investigative
Structure
Antibody Name
undisclosed
Antigen Name
Undisclosed
Payload Name
TLR7 payload 1
  Payload Info 
Therapeutic Target
Toll-like receptor 7 (TLR7)
  Target Info 
Linker Name
39948340 Linker
  Linker Info 
Conjugate Type
Direct preparation of site-specific ADC with unpurified antibodies in culture medium.
General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
Click To Hide/Show 12 Absorption Data Related to This Level
Standard Type Value Units Description Reference
Time to Maximum Concentration (Tmax) 0.25 h
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice.
 [1]
Time to Maximum Concentration (Tmax) 0.25 h
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice.
 [1]
Time to Maximum Concentration (Tmax) 0.25 h
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice.
 [1]
Maximum Observed Concentration (Cmax) 142 ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice.
 [1]
Maximum Observed Concentration (Cmax) 354 ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice.
 [1]
Maximum Observed Concentration (Cmax) 13.2 ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice.
 [1]
Area Under the Concentration-Time Curve (AUC) 8584 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 22944 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 31 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 9329 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 25597 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 372 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUCinf.
 [1]
Distribution
Click To Hide/Show 9 Distribution Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 8584 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 22944 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 31 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 9329 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 25597 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 372 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUCinf.
 [1]
Volume of Distribution (Vd) 110 mL/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice.
 [1]
Volume of Distribution (Vd) 135 mL/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice.
 [1]
Volume of Distribution (Vd) 90.6 mL/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice.
 [1]
Metabolism
Click To Hide/Show 6 Metabolism Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 8584 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 22944 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 31 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 9329 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 25597 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 372 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUCinf.
 [1]
Excretion
Click To Hide/Show 12 Excretion Data Related to This Level
Standard Type Value Units Description Reference
Area Under the Concentration-Time Curve (AUC) 8584 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 22944 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 31 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUClast.
 [1]
Area Under the Concentration-Time Curve (AUC) 9329 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 25597 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice, AUCinf.
 [1]
Area Under the Concentration-Time Curve (AUC) 372 h&#42ug/mL
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice, AUCinf.
 [1]
Elimination Half-Life (t1/2) 70.9 h
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice.
 [1]
Elimination Half-Life (t1/2) 83.5 h
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice.
 [1]
Elimination Half-Life (t1/2) 23.8 h
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice.
 [1]
Clearance (CL) 26.2 mL/day/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 10 mpk in CT26 tumor mice.
 [1]
Clearance (CL) 28.2 mL/day/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 30 mpk in CT26 tumor mice.
 [1]
Clearance (CL) 64.7 mL/day/kg
Pharmacokinetic (PK) parameters of ADC at a dose of 1 mpk in CT26 tumor mice.
 [1]
References
Ref 1 Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells