Antigen Information

General Information of This Antigen

Antigen ID	TAR0ZLIBG
Antigen Name	Envelope glycoprotein D (Gd)
Gene Name	Gd
Synonym	US6
Sequence	MGGTAARLGAVILFVVIVGLHGVRGKYALADASLKMADPNRFRGKDLPVLDQLTDPPGVR RVYHIQAGLPDPFQPPSLPITVYYAVLERACRSVLLNAPSEAPQIVRGASEDVRKQPYNL TIAWFRMGGNCAIPITVMEYTECSYNKSLGACPIRTQPRWNYYDSFSAVSEDNLGFLMHA PAFETAGTYLRLVKINDWTEITQFILEHRAKGSCKYALPLRIPPSACLSPQAYQQGVTVD SIGMLPRFIPENQRTVAVYSLKIAGWHGPKAPYTSTLLPPELSETPNATQPELAPEDPED SALLEDPVGTVAPQIPPNWHIPSIQDAATPYHPPATPNNMGLIAGAVGGSLLAALVICGI VYWMHRRTRKAPKRIRLPHIREDDQPSSHQPLFY Click to Show/Hide
Family	Herpesviridae glycoprotein D family
Function	Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL. Click to Show/Hide
Uniprot Entry	GD_HHV1P

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-gD-LC-K149C

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Alpha-gD-LC-K149C-12	Seco-CBI-dimer 12	Human Deoxyribonucleic acid (hDNA)	Mc-peptidomimetic based linker 12	[1]

Anti-Ly6E-LC-K149C

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Alpha-Ly6E-LC-K149C-10	seco-CBI-dimer	Human Deoxyribonucleic acid (hDNA)	Mc-peptidomimetic based linker 10	[1]

Thio hu Anti-gD 5B6 LC K149C

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2017059289A1 ADC-209	WO2017059289A1_ADC-209 payload	Undisclosed	WO2017059289A1_ADC-209 linker	[2]

References

Ref 1	Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 2	Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.