Antigen Information

General Information of This Antigen (ID: TAR0ZLIBG)
Antigen Name
Envelope glycoprotein D (Gd)
Gene Name
Gd
Gene ID
5047
Synonym
US6
Sequence
MGGTAARLGAVILFVVIVGLHGVRGKYALADASLKMADPNRFRGKDLPVLDQLTDPPGVR
RVYHIQAGLPDPFQPPSLPITVYYAVLERACRSVLLNAPSEAPQIVRGASEDVRKQPYNL
TIAWFRMGGNCAIPITVMEYTECSYNKSLGACPIRTQPRWNYYDSFSAVSEDNLGFLMHA
PAFETAGTYLRLVKINDWTEITQFILEHRAKGSCKYALPLRIPPSACLSPQAYQQGVTVD
SIGMLPRFIPENQRTVAVYSLKIAGWHGPKAPYTSTLLPPELSETPNATQPELAPEDPED
SALLEDPVGTVAPQIPPNWHIPSIQDAATPYHPPATPNNMGLIAGAVGGSLLAALVICGI
VYWMHRRTRKAPKRIRLPHIREDDQPSSHQPLFY

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Family
Herpesviridae glycoprotein D family
Function
Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.

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Uniprot Entry
GD_HHV1P
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-gD-LC-K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-gD-LC-K149C-12 [1]
Seco-CBI-dimer 12
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 12
 ADC Info 
Anti-Ly6E-LC-K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-Ly6E-LC-K149C-10 [1]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
 ADC Info 
Thio hu Anti-gD 5B6 LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-209 [2]
WO2017059289A1_ADC-209 payload
Undisclosed
WO2017059289A1_ADC-209 linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ab-gD-CIDE-BRM1-9
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab-gD-CIDE-BRM1-20
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab-gD-CIDE-BRM1-19
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab-gD-CIDE-BRM1-15
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 2 Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.