Antigen Information
General Information of This Antigen (ID: TAR0ZLGLD)
| Antigen Name | N-myc downstream-regulated gene 2B (NDRG2B) |
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| Gene Name | NDRG2B |
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| Synonym | KIAA1248; SYLD |
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| Sequence |
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKP
KRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPS LDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMD WAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNR RDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQP GKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSS GPPGHTMEVSC Click to Show/Hide
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| Family | NDRG family |
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| Function |
FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
AV-25
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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mAb-P5 (PEG24)- VC-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG24)- VC-PAB linker |
|
|
mAb-P5 (PEG2)- VC-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG2)- VC-PAB linker |
|
|
mAb-P5 (PEG12)- VC-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12)- VC-PAB linker |
|
|
mAb-P5 (PEG2)-VA-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG2)-VA-PAB linker |
|
|
mAb-P5 (PEG12)-VA-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12)-VA-PAB linker |
|
|
mAb-P5 (PEG24)-VA-PAB-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG24)-VA-PAB linker |
|
|
mAb-P5 (PEG2)-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG2) linker |
|
|
mAb-P5 (PEG12)-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG12) linker |
|
|
mAb-P5 (PEG24)-Exatecan
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
P5 (PEG24) linker |
|
|
mAb-P5 (PEG12)- VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG12)- VC-PAB linker |
|
|
mAb-P5 (PEG24)- VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG24)- VC-PAB linker |
|
|
mAb-P5 (PEG2)- VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG2)- VC-PAB linker |
|
|
mAb-P5 (PEG12)-VA-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG12)-VA-PAB linker |
|
|
mAb-P5 (PEG2)-VA-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG2)-VA-PAB linker |
|
|
mAb-P5 (PEG24)-VA-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
P5 (PEG24)-VA-PAB linker |
References