Antigen Information

General Information of This Antigen (ID: TAR0ZKUXH)
Antigen Name
Neuronal pentraxin receptor (NPTXR)
Gene Name
NPTXR
Gene ID
23467
Synonym
NPTXR
Sequence
MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLS
ALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGER
EELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMA
DGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEG
QLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPI
RNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPME
LLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGIL
ILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLV
EAFGGATKAAFDVCKGRAKA

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Function
FUNCTION: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250}.

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Uniprot Entry
NPTXR_HUMAN
HGNC ID
HGNC:7954 ,
KEGG ID
hsa:23467
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
YB-800 MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
YB-800 Exatecan [1]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
References
Ref 1 PCO25-210: Design of Novel Antibody Drug Conjugates Using a Fully Humanized Monoclonal Antibody Targeting the Human Neuronal Pentraxin Receptor (YB800-ADCs) for Therapeutic Intervention in Oncology