Antigen Information

General Information of This Antigen
Antigen ID
TAR0ZDFGV
Antigen Name
Prostate-specific antigen (KLK3)
Gene Name
KLK3
Gene ID
354
Synonym
APS; Gamma-seminoprotein;Kallikrein-3;P-30 antigen;Semenogelase
Sequence
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWV
LTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHD
LMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVIS
NDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERP
SLYTKVVHYRKWIKDTIVANP

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Family
Peptidase S1 family
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

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Uniprot Entry
KLK3_HUMAN
HGNC ID
HGNC:6364
KEGG ID
hsa:354
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-KLK3 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MagSense PSA
Undisclosed
Undisclosed
Undisclosed
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ANP-020
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
ADCT-212
SG2000
Human Deoxyribonucleic acid (hDNA)
Vali-Ala cleavable linker
 [3]
References
Ref 1 Introduction to basic information on ADC drug MagSense PSA
Ref 2 Introduction to basic information on ADC drug ANP-020.
Ref 3 Preclinical development of ADCT-212, a PSMA-targeted antibody-drug conjugate employing the pyrrolobenzodiazepine dimer SG2000 for PSMA-expressing cancers. Cancer Res (2023) 83 (7_Supplement): 2638.