Antigen Information

General Information of This Antigen (ID: TAR0ZDFGV)
Antigen Name
Prostate-specific antigen (KLK3)
Gene Name
KLK3
Gene ID
354
Synonym
APS; Gamma-seminoprotein;Kallikrein-3;P-30 antigen;Semenogelase
Sequence
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWV
LTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHD
LMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVIS
NDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERP
SLYTKVVHYRKWIKDTIVANP

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Family
Peptidase S1 family
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

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Uniprot Entry
KLK3_HUMAN
HGNC ID
HGNC:6364
KEGG ID
hsa:354
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-KLK3 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MagSense PSA [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ANP-020 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADCT-212 [3]
SG2000
Human Deoxyribonucleic acid (hDNA)
Vali-Ala cleavable linker
 ADC Info 
References
Ref 1 Introduction to basic information on ADC drug MagSense PSA
Ref 2 Introduction to basic information on ADC drug ANP-020.
Ref 3 Preclinical development of ADCT-212, a PSMA-targeted antibody-drug conjugate employing the pyrrolobenzodiazepine dimer SG2000 for PSMA-expressing cancers. Cancer Res (2023) 83 (7_Supplement): 2638.