Antigen Information

General Information of This Antigen
Antigen ID
TAR0YUFBV
Antigen Name
Prostaglandin F2 receptor negative regulator (PTGFRN)
Gene Name
PTGFRN
Gene ID
5738
Synonym
CD9P1; EWIF; FPRP; KIAA1436; CD9 partner 1;Glu-Trp-Ile EWI motif-containing protein F;Prostaglandin F2-alpha receptor regulatory protein;Prostaglandin F2-alpha receptor-associated protein;CD_antigen=CD315
Sequence
MGRLASRPLLLALLSLALCRGRVVRVPTATLVRVVGTELVIPCNVSDYDGPSEQNFDWSF
SSLGSSFVELASTWEVGFPAQLYQERLQRGEILLRRTANDAVELHIKNVQPSDQGHYKCS
TPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLREGEPFELRCTAASASPLHTH
LALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSGDVRLDTVGSDAYRLSVSRALSA
DQGSYRCIVSEWIAEQGNWQEIQEKAVEVATVVIQPSVLRAAVPKNVSVAEGKELDLTCN
ITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARLDRDSLVHSSPHVALSHVDARSYHLLV
RDVSKENSGYYYCHVSLWAPGHNRSWHKVAEAVSSPAGVGVTWLEPDYQVYLNASKVPGF
ADDPTELACRVVDTKSGEANVRFTVSWYYRMNRRSDNVVTSELLAVMDGDWTLKYGERSK
QRAQDGDFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTKQRNNSWVKSKDVFSKPVN
IFWALEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLIMAEKPVGDLSSPN
ETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAW
SPVRGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTPSVIRGDLIKLFCIITVEGAAL
DPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGIVTTSRRDWKSDLSLERVSVLEFLLQV
HGSEDQDFGNYYCSVTPWVKSPTGSWQKEAEIHSKPVFITVKMDVLNAFKYPLLIGVGLS
TVIGLLSCLIGYCSSHWCCKKEVQETRRERRRLMSMEMD

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Function
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur. In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration.

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Uniprot Entry
FPRP_HUMAN
HGNC ID
HGNC:9601
KEGG ID
hsa:5738
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-PTGFRN mAb 33B7
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
33B7-Saporin
Saporin
Microtubule (MT)
Undisclosed
 [1]
References
Ref 1 Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development. PLoS One. 2021 Jan 27;16(1):e0246197. doi: 10.1371/journal.pone.0246197. eCollection 2021.

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