Antigen Information

General Information of This Antigen
Antigen ID
TAR0XTVJE
Antigen Name
Tax1-binding protein 3 (TAX1BP3)
Gene Name
TAX1BP3
Gene ID
30851
Synonym
Glutaminase-interacting protein 3;Tax interaction protein 1;Tax-interacting protein 1
Sequence
MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRV
SEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
SMLS

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Function
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

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Uniprot Entry
TX1B3_HUMAN
HGNC ID
HGNC:30684
KEGG ID
hsa:30851
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-TIP1 mAb 7H5
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
7H5-Val-Cit-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
References
Ref 1 Targeting a Radiosensitizing Antibody-Drug Conjugate to a Radiation-Inducible Antigen. Clin Cancer Res. 2021 Jun 1;27(11):3224-3233. doi: 10.1158/1078-0432.CCR-20-1725.

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