Antigen Information

General Information of This Antigen (ID: TAR0WTJOW)
Antigen Name
Alkaline phosphatase, germ cell type (ALPG); Alkaline phosphatase, placental type (ALPP)
Gene Name
ALPG; ALPP
Gene ID
251 , 250
Synonym1
ALP-1;Alkaline phosphatase Nagao isozyme;Alkaline phosphatase, placental-like;Germ cell alkaline phosphatase;Placental alkaline phosphatase-like
Synonym2
PLAP
Sequence1
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

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Sequence2
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP

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Family1
AF4 family
Function1
Alkaline phosphatase that can hydrolyze various phosphate compounds.

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Function2
Alkaline phosphatase that can hydrolyze various phosphate compounds.

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Uniprot Entry
PPBN_HUMAN , PPB1_HUMAN
HGNC ID
HGNC:441 , HGNC:439
KEGG ID
hsa:251 , hsa:250
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AT2604 [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 AT2604 is a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2