Antigen Information

General Information of This Antigen
Antigen ID
TAR0WFMGA
Antigen Name
High affinity immunoglobulin gamma Fc receptor I (Fcgr1)
Gene Name
Fcgr1
Synonym
FCG1; FCGR1; IGFR1
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
LQEGVHRKEPQGAT

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Family
Immunoglobulin superfamily, FCGR1 family
Function
FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:11711607, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.

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Uniprot Entry
FCGR1_HUMAN
HGNC ID
HGNC:3613 ,
KEGG ID
hsa:2209 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
H22 (scFv)-SNAP
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD64 (scFv)-SNAP-Auristatin F
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 [1]
References
Ref 1 Anti-CD64(scFv)-SNAP-Auristatin F: An in vitro proof of concept study for a recombinant antibody conjugate targeting CD64(+) acute monocytic leukemia