Antigen Information

General Information of This Antigen (ID: TAR0WFMGA)
Antigen Name
High affinity immunoglobulin gamma Fc receptor I (Fcgr1)
Gene Name
Fcgr1
Gene ID
2209
Synonym
FCG1; FCGR1; IGFR1
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
LQEGVHRKEPQGAT

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Family
Immunoglobulin superfamily, FCGR1 family
Function
FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:11711607, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.

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Uniprot Entry
FCGR1_HUMAN
HGNC ID
HGNC:3613 ,
KEGG ID
hsa:2209
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
H22 (scFv)-SNAP
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD64 (scFv)-SNAP-Auristatin F [1]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Anti-CD64(scFv)-SNAP-Auristatin F: An in vitro proof of concept study for a recombinant antibody conjugate targeting CD64(+) acute monocytic leukemia