Antigen Information

General Information of This Antigen
Antigen ID
TAR0VTXKI
Antigen Name
Teratocarcinoma-derived growth factor 1 (TDGF1)
Gene Name
TDGF1
Gene ID
6997
Synonym
CRIPTO; Cripto-1 growth factor;Epidermal growth factor-like cripto protein CR1
Sequence
MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIR
PRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPH
DTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGI
CLSIQSYY

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Family
COLEC10/COLEC11 family
Function
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

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Uniprot Entry
TDGF1_HUMAN
HGNC ID
HGNC:11701
KEGG ID
hsa:6997
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-TDGF1 mAb huB3F6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BIIB-015
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [1]
References
Ref 1 An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours. Eur J Cancer. 2011 Jul;47(11):1736-46.

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