Antigen Information
General Information of This Antigen (ID: TAR0VTXKI)
| Antigen Name | Teratocarcinoma-derived growth factor 1 (TDGF1) |
|||||
|---|---|---|---|---|---|---|
| Gene Name | TDGF1 |
|||||
| Gene ID | ||||||
| Synonym | CRIPTO; Cripto-1 growth factor;Epidermal growth factor-like cripto protein CR1 |
|||||
| Sequence |
MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIR
PRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPH DTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGI CLSIQSYY Click to Show/Hide
|
|||||
| Family | COLEC10/COLEC11 family |
|||||
| Function |
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Click to Show/Hide
|
|||||
| Uniprot Entry | ||||||
| HGNC ID | ||||||
| KEGG ID | ||||||
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
HuB3F6
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
BIIB015
|
DM4 |
Microtubule (MT) |
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB) |