General Information of This Antigen (ID: TAR0UBWTY)
Antigen Name
Translocator protein (TSPO)
Gene Name
TSPO
Gene ID
706
Synonym
BZRP; MBR; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor
Sequence
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

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Family
TspO/BZRP family
Function
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral- type benzodiazepine receptor; can also bind isoquinoline carboxamides.

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Uniprot Entry
TSPO_HUMAN
HGNC ID
HGNC:1158
KEGG ID
hsa:706
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-SAIL mAb
ADC Name Payload Target Linker ADC Info
IGN-786 [1]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
References
Ref 1 Introduction to basic information on ADC drug IGN-786