Antigen ID	TAR0UBNCZ
Antigen Name	Syndecan-1 (SDC1); Integrin alpha-4 (ITGA4)
Gene Name	SDC1; ITGA4
Gene ID	6382
Synonym1	SDC; CD_antige=nCD138
Synonym2	CD49D; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen=CD49d
Sequence1	MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQ TPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQE ATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHT EDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGAT GASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQ KPTKQEEFYA     Click to Show/Hide
Sequence2	MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD SWSYINSKSNDD     Click to Show/Hide
Family2	Integrin alpha chain family
Function1	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.     Click to Show/Hide
Function2	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.     Click to Show/Hide
Uniprot Entry	SDC1_HUMAN , ITA4_HUMAN
HGNC ID	HGNC:10658 , HGNC:6140
KEGG ID	hsa:6382 , hsa:3676

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Bispecific nBT062-natalizumab-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[1]

Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.040476003; Fold-change: -0.071147307; Z-score: -0.275625311
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Differential expression pattern of antigen in diseases
The Studied Tissue	White matter
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000860769; Fold-change: 0.723919588; Z-score: 1.654610517
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The Studied Tissue	Brainstem
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000334842; Fold-change: 0.477995488; Z-score: 7.052568499
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The Studied Tissue	Brainstem
The Specific Disease	Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.15E-07; Fold-change: 0.662444752; Z-score: 1.603334847
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The Studied Tissue	Nervous
The Specific Disease	Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.76E-60; Fold-change: 0.568919909; Z-score: 1.05372912
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.174523561; Fold-change: 0.062570559; Z-score: 0.467319817
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The Studied Tissue	Whole blood
The Specific Disease	Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.58E-05; Fold-change: 0.117593319; Z-score: 0.832368187
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.59944863; Fold-change: -0.152730217; Z-score: -0.569517792
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.052253762; Fold-change: 0.114990655; Z-score: 0.810587474
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Tonsil
The Specific Disease	Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.706066723; Fold-change: -0.223671035; Z-score: -1.160862966
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric
The Specific Disease	Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.53528938; Fold-change: 0.594394522; Z-score: 0.300207767
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.026591422; Fold-change: 0.010040289; Z-score: 0.023912169
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon
The Specific Disease	Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.63E-05; Fold-change: -0.102223815; Z-score: -0.373659263
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.286950309; Fold-change: -0.006279184; Z-score: -0.009084405
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pancreas
The Specific Disease	Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.37E-07; Fold-change: 1.637616007; Z-score: 1.849542899
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.93E-23; Fold-change: 1.827354003; Z-score: 2.29013514
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000893792; Fold-change: -0.190076736; Z-score: -0.374925915
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 9.89E-12; Fold-change: -0.224052365; Z-score: -0.641085137
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.734542024; Fold-change: 0.116924847; Z-score: 0.510623946
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.40E-28; Fold-change: 0.584429407; Z-score: 1.494462129
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 3.08E-29; Fold-change: 0.747969719; Z-score: 1.594218476
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.025150119; Fold-change: -1.401983326; Z-score: -0.773294395
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.04E-140; Fold-change: 2.305899409; Z-score: 8.784569166
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.22E-20; Fold-change: 2.56460858; Z-score: 23.84474651
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Differential expression pattern of antigen in diseases
The Studied Tissue	Breast
The Specific Disease	Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.27E-73; Fold-change: 1.419066558; Z-score: 1.373004701
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 4.61E-13; Fold-change: 1.321078824; Z-score: 1.350788881
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Differential expression pattern of antigen in diseases
The Studied Tissue	Ovarian
The Specific Disease	Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.17E-07; Fold-change: 2.122237653; Z-score: 4.655151952
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.065881537; Fold-change: 0.615988745; Z-score: 0.367538089
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Cervical
The Specific Disease	Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000692169; Fold-change: -0.258951024; Z-score: -0.795637831
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.95E-08; Fold-change: 1.005558068; Z-score: 0.640349825
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.002494071; Fold-change: 0.706202955; Z-score: 1.762660543
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Prostate
The Specific Disease	Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.002428339; Fold-change: -0.087346598; Z-score: -0.119872007
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.675520597; Fold-change: 0.148247437; Z-score: 0.223562619
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Differential expression pattern of antigen in diseases
The Studied Tissue	Uvea
The Specific Disease	Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.17E-05; Fold-change: 0.863525048; Z-score: 5.430371399
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Differential expression pattern of antigen in diseases
The Studied Tissue	Thyroid
The Specific Disease	Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.06E-08; Fold-change: 0.384678206; Z-score: 0.859051249
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.13E-05; Fold-change: 0.63063012; Z-score: 0.983815551
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adrenal cortex
The Specific Disease	Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.027570299; Fold-change: 0.284267841; Z-score: 0.409663152
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Differential expression pattern of antigen in diseases
The Studied Tissue	Head and neck
The Specific Disease	Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.81E-07; Fold-change: 0.606945128; Z-score: 0.713648944
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pituitary
The Specific Disease	Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.714827919; Fold-change: -0.125802715; Z-score: -0.529530419
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The Studied Tissue	Pituitary
The Specific Disease	Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.01417975; Fold-change: 0.221577786; Z-score: 0.908547174
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.055015081; Fold-change: 0.461904158; Z-score: 1.653110626
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.84E-08; Fold-change: 0.140704615; Z-score: 0.470010298
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral monocyte
The Specific Disease	Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.016176617; Fold-change: -0.14109845; Z-score: -1.200254354
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000164376; Fold-change: -0.348398104; Z-score: -1.198979054
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Differential expression pattern of antigen in diseases
The Studied Tissue	Superior temporal cortex
The Specific Disease	Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.207636291; Fold-change: -0.067020709; Z-score: -0.71375319
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Differential expression pattern of antigen in diseases
The Studied Tissue	Spinal cord
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.062792544; Fold-change: -0.172216865; Z-score: -0.466004246
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Plasmacytoid dendritic cells
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.823804203; Fold-change: -0.024517295; Z-score: -0.081199326
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peritumoral cortex
The Specific Disease	Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.592682896; Fold-change: 0.009197339; Z-score: 0.018726126
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.002255019; Fold-change: 0.138023775; Z-score: 0.553399747
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The Studied Tissue	Peripheral blood
The Specific Disease	Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.796599739; Fold-change: 0.051501199; Z-score: 0.369998915
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	White matter
The Specific Disease	HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.167447721; Fold-change: 0.043526892; Z-score: 0.455350333
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.027263563; Fold-change: 0.184899853; Z-score: 3.64057613
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.006742793; Fold-change: 0.102728582; Z-score: 0.973547288
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.713816746; Fold-change: -0.024146943; Z-score: -0.105615846
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.22E-06; Fold-change: 0.064444426; Z-score: 0.262648822
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.063947198; Fold-change: 0.053623094; Z-score: 0.390315441
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.372897058; Fold-change: 0.378464302; Z-score: 2.854753007
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.539831727; Fold-change: 0.057221519; Z-score: 0.091499788
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.82601391; Fold-change: 0.070285938; Z-score: 0.391424839
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Calcified aortic valve
The Specific Disease	Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.009293282; Fold-change: 0.620883968; Z-score: 1.639315271
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.474330546; Fold-change: 0.031792414; Z-score: 0.239878496
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Differential expression pattern of antigen in diseases
The Studied Tissue	Intracranial artery
The Specific Disease	Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.61E-06; Fold-change: 1.27438611; Z-score: 5.941272729
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.237386722; Fold-change: 0.091450621; Z-score: 0.8271442
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Differential expression pattern of antigen in diseases
The Studied Tissue	Hyperplastic tonsil
The Specific Disease	Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.526941023; Fold-change: -0.023990327; Z-score: -0.043834743
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.642509194; Fold-change: 0.145290102; Z-score: 0.481829187
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Differential expression pattern of antigen in diseases
The Studied Tissue	Sinus mucosa
The Specific Disease	Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.859678104; Fold-change: -0.122672299; Z-score: -0.265442252
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.097687157; Fold-change: -0.104109618; Z-score: -0.353798986
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The Studied Tissue	Small airway epithelium
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.069553457; Fold-change: -0.070678261; Z-score: -0.101305017
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal and bronchial airway
The Specific Disease	Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.28E-07; Fold-change: 0.672200955; Z-score: 0.608082062
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal Epithelium
The Specific Disease	Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.439506905; Fold-change: 0.046506737; Z-score: 0.132537511
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.001278483; Fold-change: 0.997474378; Z-score: 2.395371815
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.005096091; Fold-change: -0.104970637; Z-score: -0.414631389
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric antrum
The Specific Disease	Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.403700424; Fold-change: 0.475710204; Z-score: 1.583953621
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000115964; Fold-change: -1.250617446; Z-score: -2.516993002
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon mucosal
The Specific Disease	Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.028164164; Fold-change: 0.193703367; Z-score: 0.416826267
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.225579201; Fold-change: -0.03210857; Z-score: -0.186994756
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000864939; Fold-change: -0.317297893; Z-score: -1.532394389
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.78E-11; Fold-change: 0.210943746; Z-score: 0.560956312
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.51E-12; Fold-change: -0.611868406; Z-score: -1.658981278
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.710015274; Fold-change: -0.013474412; Z-score: -0.138647742
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin from scalp
The Specific Disease	Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.07E-13; Fold-change: -0.225284274; Z-score: -2.679209472
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.543082526; Fold-change: 0.02732144; Z-score: 0.16550282
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.216713363; Fold-change: 1.335094798; Z-score: 0.825105174
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.550156734; Fold-change: -0.0292284; Z-score: -0.262655068
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.079644301; Fold-change: 0.075093783; Z-score: 0.194001007
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.81E-10; Fold-change: 2.432143409; Z-score: 7.86198682
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pheripheral blood
The Specific Disease	Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.978491895; Fold-change: 0.122920786; Z-score: 0.164591521
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.770711463; Fold-change: 0.009181999; Z-score: 0.013249299
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.063683376; Fold-change: 0.665293267; Z-score: 0.909711811
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000111059; Fold-change: -1.421583505; Z-score: -4.295830958
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Differential expression pattern of antigen in diseases
The Studied Tissue	Myometrium
The Specific Disease	Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.636543199; Fold-change: -0.281954127; Z-score: -1.715073624
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.57E-12; Fold-change: -0.398182277; Z-score: -0.664313561
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.878278705; Fold-change: 0.050250933; Z-score: 0.308039511
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The Studied Tissue	Bone marrow
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.001622929; Fold-change: 0.763818394; Z-score: 2.174780832
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Differential expression pattern of antigen in diseases
The Studied Tissue	Oral
The Specific Disease	Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.018042326; Fold-change: 0.450463966; Z-score: 0.323660173
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.941401831; Fold-change: -0.18161519; Z-score: -0.134987399
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Esophagus
The Specific Disease	Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.250481313; Fold-change: -0.974714301; Z-score: -1.021774348
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.338613993; Fold-change: -0.035399855; Z-score: -0.189048327
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.929666466; Fold-change: 0.056120715; Z-score: 0.201413812
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.74E-66; Fold-change: -1.973474937; Z-score: -4.065499956
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.92E-76; Fold-change: -2.408912784; Z-score: -3.892348817
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Kidney
The Specific Disease	Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.009066772; Fold-change: -1.601716586; Z-score: -1.422518177
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 3.37E-47; Fold-change: -1.716930907; Z-score: -3.335950333
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Differential expression pattern of antigen in diseases
The Studied Tissue	Urothelium
The Specific Disease	Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.587405512; Fold-change: 0.118142248; Z-score: 0.129482681
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adipose
The Specific Disease	Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.948799518; Fold-change: 0.016553718; Z-score: 0.085880034
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Differential expression pattern of antigen in diseases
The Studied Tissue	Perituberal
The Specific Disease	Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.099459748; Fold-change: 0.365896952; Z-score: 3.001743359
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.101724661; Fold-change: 0.339444618; Z-score: 0.88610707
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.079369097; Fold-change: 0.059563554; Z-score: 0.478734256
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.043815123; Fold-change: 0.043028959; Z-score: 0.30746291
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.755440279; Fold-change: 0.041342612; Z-score: 0.211191323
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Differential expression pattern of antigen in diseases
The Studied Tissue	Salivary gland
The Specific Disease	Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.257306783; Fold-change: 0.49507485; Z-score: 0.879758392
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.188443621; Fold-change: -0.207983611; Z-score: -1.268401476
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.164066345; Fold-change: 0.051515059; Z-score: 0.375007926
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.041008021; Fold-change: 0.14583286; Z-score: 2.092575274
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.39198187; Fold-change: -0.11222421; Z-score: -0.413392765
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Differential expression pattern of antigen in diseases
The Studied Tissue	Vastus lateralis muscle
The Specific Disease	Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.785380875; Fold-change: -0.025121912; Z-score: -0.134764051
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Differential expression pattern of antigen in diseases
The Studied Tissue	Subcutaneous Adipose
The Specific Disease	Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.992777754; Fold-change: -0.033269701; Z-score: -0.24471621
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Differential expression pattern of antigen in diseases
The Studied Tissue	Biceps muscle
The Specific Disease	Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.268432425; Fold-change: -0.121029522; Z-score: -0.447271083
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.142870975; Fold-change: -0.073854997; Z-score: -0.367048116
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.141991452; Fold-change: -0.068856166; Z-score: -0.252594892
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.227296053; Fold-change: 0.069562436; Z-score: 0.24974894
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Differential expression pattern of antigen in diseases
The Studied Tissue	Substantia nigra
The Specific Disease	Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.024242127; Fold-change: -0.776091928; Z-score: -0.94333867
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.717714507; Fold-change: 0.100629233; Z-score: 0.522359631
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Differential expression pattern of antigen in diseases
The Studied Tissue	Entorhinal cortex
The Specific Disease	Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.22E-05; Fold-change: -0.081386073; Z-score: -0.401652766
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.696710563; Fold-change: 0.074791958; Z-score: 0.327673036
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.148631648; Fold-change: 0.32691598; Z-score: 0.791840477
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The Studied Tissue	Cervical spinal cord
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.400107064; Fold-change: -0.065519602; Z-score: -0.316735009
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.005499958; Fold-change: -0.159953079; Z-score: -1.075949476
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.001391721; Fold-change: 0.34371134; Z-score: 2.364789234
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

Ref 1	Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS One. 2018 Apr 19;13(4):e0195823. doi: 10.1371/journal.pone.0195823. eCollection 2018.