Antigen Information

General Information of This Antigen
Antigen ID
TAR0TXBRL
Antigen Name
C-C chemokine receptor type 4 (CCR4)
Gene Name
CCR4
Gene ID
1233
Synonym
CMKBR4; K5-5; CD_antigen=CD194
Sequence
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

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Family
G-protein coupled receptor 1 family
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

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Uniprot Entry
CCR4_HUMAN
HGNC ID
HGNC:1605
KEGG ID
hsa:1233
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Name Payload Target Linker ADC Info
CCR4-IL2 IT [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IL2-CCR4 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
IL2-CCR4 immunotoxin [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IL2 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
CCR4 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
References
Ref 1 CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model. FEBS Open Bio. 2023 Jul;13(7):1309-1319. doi: 10.1002/2211-5463.13625. Epub 2023 May 15.
Ref 2 Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020 May;14(5):991-1000. doi: 10.1002/1878-0261.12653. Epub 2020 Mar 13.