Antigen Information
General Information of This Antigen (ID: TAR0SNDDA)
| Antigen Name | Asialoglycoprotein receptor 1 (ASGR1) |
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| Gene Name | ASGR1 |
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| Synonym | CLEC4H1; C-type lectin domain family 4 member H1;Hepatic lectin H1 |
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| Sequence |
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIG
SQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDH SSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADN YCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQ PDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL Click to Show/Hide
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| Function |
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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SBT-8230
[1]
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TLR8 agonist |
Toll-like receptor 8 (TLR8) |
Undisclosed |
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TGF-beta-R antagonist
[2]
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TGFBR2 antagonist |
TGF-beta receptor type-2 (TGFBR2) |
Undisclosed |
References